CELL BIOLOGY: A Last GASP for GPCRs?

The Last Gasp

of opportunity was, however, also a period of intense competition. Cotton’s river inter-linking scheme was double edged; it had to draw capital investments for navigation and irrigation schemes while simultaneously starving the same for the railways, which was then being touted as the most viable mode for mass transport in India. Cotton, in effect, wanted river navigation to trump railway lines...

The Last Gasp Ii: Lungs and Thorax

Prednisone: the last gasp of immunosuppresive therapy for restenosis prevention.

Once restenosis was recognized as a major limitation of percutaneous coronary intervention (PCI), investigations probed the mechanisms and developed therapeutic antirestenosis strategies to combat this phenomenon. Early on in the efforts to understand the mechanisms responsible for restenosis, two primary processes were identified following mechanical injury by the balloon angioplasty to the ve...

Reliability: Reality or the Power Engineers' Last Gasp

Power systems reliability in North America has been defined largely (if not entirely) by engineers and in engineering terms. The NERC and the regional reliability councils have traditionally been the writers of the rules and the enforcers of the requirements. Their decisions have been based on increasingly refined engineering rules of thumb that have stressed conservative measures of system sec...

The agony of agonal respiration: is the last gasp necessary?

Gasping respiration in the dying patient is the last respiratory pattern prior to terminal apnoea. The duration of the gasping respiration phase varies; it may be as brief as one or two breaths to a prolonged period of gasping lasting minutes or even hours. Gasping respiration is very abnormal, easy to recognise and distinguish from other respiratory patterns and, in the dying patient who has e...